Bioinformatics and Computational Biology

tree of life diagramOur researchers work on core computational biology-related problems, including genomics, proteomics, metagenomics, and phylogenomics. We develop novel techniques that combine ideas from mathematics, computer science, probability, statistics, and physics, and we help identify and formalize computational challenges in the biological domain, while experimentally validating novel hypotheses generated by our analyses.

We are developing algorithms with improved accuracy for large-scale and complex estimation problems in phylogenomics (genome-scale phylogeny estimation), multiple sequence alignment, and metagenomics. We are exploring gene regulation—developing advanced techniques to predict the diverse function of noncoding parts of DNA and to relate interspecies and interpersonal differences in DNA to differences in the organism’s form and function. We work broadly in the development of machine learning techniques for computational biology, with research spanning the areas of molecular and structural biology; networks and systems biology; and molecular mechanisms of human disease.

CS Faculty and Their Research Interests

Mohammed El-Kebir phylogenetics
Jiawei Han data mining for genomics and medical informatics
Jian Peng bioinformatics, protein function & structure, systems biology, machine learning and optimization
Saurabh Sinha bioinformatics, gene regulation, comparative genomics, sequence analysis
Tandy Warnow bioinformatics, multiple sequence alignment, phylogenomics, metagenomics, and historical linguistics
ChengXiang Zhai information retrieval, natural language processing for medical informatics

Bioinformatics and Computational Biology Research Efforts and Groups

Bioinformatics and Computational Biology Research News

Researchers have combined a fully automated robotic platform with artificial intelligence to develop a new way to manufacture chemicals.

Artificial Intelligence to Run the Chemical Factories of the Future

November 13, 2019   Researchers have combined a fully automated robotic platform with artificial intelligence to develop a new way to manufacture chemicals.
International consortium of researchers generates gene sequences from more than 1100 plant species.

Study Provides Framework for 1 Billion Years of Green Plant Evolution

October 23, 2019   Prof. Warnow helps an international consortium construct a large evolutionary tree of green plants, using advanced algorithms.
Five accomplished Illinois Computer Science master’s students have been recognized for their academic achievements and leadership.

Meet the Siebel Scholars Class of 2020

October 2, 2019   Five accomplished Illinois Computer Science master’s students have been recognized for their academic achievements and leadership.
New faculty bring expertise in everything from natural language processing, robotics, and security to biomedical informatics.

Illinois CS Adds Eight New Faculty, Broadening Expertise in NLP, Security, Robotics, and More

September 5, 2019   New faculty bring expertise in everything from natural language processing, robotics, and security to biomedical informatics.
Founder Professor on Engineering Tandy Warnow

Linguistics Paper Co-authored By Warnow Settled Key Questions, Honored for Its Influence

June 11, 2019   Tandy Warnow and collaborator Donald Ringe developed mathematical models that assumed language evolution followed a treelike pattern.